Prefrontal alterations in Parkinson's disease with levodopa-induced dyskinesia during fMRI motor task.
Identifieur interne : 000C55 ( Main/Exploration ); précédent : 000C54; suivant : 000C56Prefrontal alterations in Parkinson's disease with levodopa-induced dyskinesia during fMRI motor task.
Auteurs : Antonio Cerasa [Italie] ; Pierfrancesco Pugliese ; Demetrio Messina ; Maurizio Morelli ; Maria Cecilia Gioia ; Maria Salsone ; Fabiana Novellino ; Giuseppe Nicoletti ; Gennarina Arabia ; Aldo QuattroneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Antiparkinson Agents (adverse effects), Brain Mapping, Dyskinesia, Drug-Induced (pathology), Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Levodopa (adverse effects), Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity (physiology), Oxygen (blood), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Prefrontal Cortex (blood supply), Prefrontal Cortex (drug effects), Regression Analysis, Severity of Illness Index.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , blood : Oxygen.
- blood supply : Prefrontal Cortex.
- drug effects : Prefrontal Cortex.
- drug therapy : Parkinson Disease.
- pathology : Dyskinesia, Drug-Induced, Parkinson Disease.
- physiology : Motor Activity.
- Adult, Brain Mapping, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Regression Analysis, Severity of Illness Index.
Abstract
Levodopa-induced dyskinesia represents disabling complication of long-term therapy with dopaminergic drugs in treating Parkinson's disease (PD). Recently, our group demonstrated that PD patients with levodopa-induced dyskinesia were characterized by abnormal volumetric changes in the inferior prefrontal gyrus. In this study, the functional relevance of this structural abnormality was explored using functional magnetic resonance imaging. Ten dyskinetic PD patients and 10 nondyskinetic PD patients were studied in the OFF phase with functional magnetic resonance imaging while performing externally and internally triggered visuomotor tasks. Although neither group demonstrated behavioral differences during execution of motor tasks, magnetic resonance imaging analysis detected significant changes in target cortical regions. In particular, PD patients with levodopa-induced dyskinesia showed significant overactivity in the supplementary motor area and underactivity in the right inferior prefrontal gyrus during execution of both tasks when compared with PD patients without levodopa-induced dyskinesia. Moreover, these prefrontal functional alterations were significantly correlated with Abnormal Involuntary Movement Scale scores. This functional magnetic resonance imaging study together with our previous volumetric findings highlights the role of the prefrontal cortex in the neuronal mechanisms of dyskinesia.
DOI: 10.1002/mds.24017
PubMed: 22076870
Affiliations:
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Le document en format XML
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first="Demetrio" last="Messina">Demetrio Messina</name></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name></author><author><name sortKey="Gioia, Maria Cecilia" sort="Gioia, Maria Cecilia" uniqKey="Gioia M" first="Maria Cecilia" last="Gioia">Maria Cecilia Gioia</name></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></author><author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name></author><author><name 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task.</title><author><name sortKey="Cerasa, Antonio" sort="Cerasa, Antonio" uniqKey="Cerasa A" first="Antonio" last="Cerasa">Antonio Cerasa</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, Germaneto (CZ), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, Germaneto (CZ)</wicri:regionArea><wicri:noRegion>Germaneto (CZ)</wicri:noRegion></affiliation></author><author><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name></author><author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name></author><author><name sortKey="Gioia, Maria Cecilia" sort="Gioia, Maria Cecilia" uniqKey="Gioia M" first="Maria Cecilia" last="Gioia">Maria Cecilia Gioia</name></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></author><author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiparkinson Agents (adverse effects)</term><term>Brain Mapping</term><term>Dyskinesia, Drug-Induced (pathology)</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Levodopa (adverse effects)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Oxygen (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Prefrontal Cortex (blood supply)</term><term>Prefrontal Cortex (drug effects)</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa-induced dyskinesia represents disabling complication of long-term therapy with dopaminergic drugs in treating Parkinson's disease (PD). Recently, our group demonstrated that PD patients with levodopa-induced dyskinesia were characterized by abnormal volumetric changes in the inferior prefrontal gyrus. In this study, the functional relevance of this structural abnormality was explored using functional magnetic resonance imaging. Ten dyskinetic PD patients and 10 nondyskinetic PD patients were studied in the OFF phase with functional magnetic resonance imaging while performing externally and internally triggered visuomotor tasks. Although neither group demonstrated behavioral differences during execution of motor tasks, magnetic resonance imaging analysis detected significant changes in target cortical regions. In particular, PD patients with levodopa-induced dyskinesia showed significant overactivity in the supplementary motor area and underactivity in the right inferior prefrontal gyrus during execution of both tasks when compared with PD patients without levodopa-induced dyskinesia. Moreover, these prefrontal functional alterations were significantly correlated with Abnormal Involuntary Movement Scale scores. This functional magnetic resonance imaging study together with our previous volumetric findings highlights the role of the prefrontal cortex in the neuronal mechanisms of dyskinesia.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><name sortKey="Gioia, Maria Cecilia" sort="Gioia, Maria Cecilia" uniqKey="Gioia M" first="Maria Cecilia" last="Gioia">Maria Cecilia Gioia</name><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></noCountry><country name="Italie"><noRegion><name sortKey="Cerasa, Antonio" sort="Cerasa, Antonio" uniqKey="Cerasa A" first="Antonio" last="Cerasa">Antonio Cerasa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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